神经突触素3抗体
规格：1尘驳/1尘濒
英文名： Synapsin III
别名： SYN 3; SYN-3; SYN3; Synapsin 3; Synapsin3; Synapsin-3; cN28H9.2 (synapsin III); OTTHUMP00000028987; SYN3_HUMAN.
分子量： 63kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Synapsin
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
神经突触素3抗体产物介绍：background: Synapsins are synaptic vesicle-associated phosphoproteins that regulate synaptic vesicle exocytosis and may be involved in synaptogenesis. Evidence suggests that Synapsin I, Synapsin II and Synapsin IIIa are ATP-binding proteins that are regulated by Ca2+ and calmodulin binding. Ca2+ has been shown to stimulate ATP binding to Synapsin I, to have no effect on Synapsin II and to inhibit Synapsin III. Synapsin I and Synapsin II both undergo alternative splicing to produce two forms of each protein, Synapsin la and lb and Synapsin IIa and IIb, respectively. Synapsin III gives rise to at least three isoforms: Synapsin IIIa, IIIb and IIIc. Synapsin III plays unique roles both 神经突触素3抗体in early axon outgrowth and in the regulation of synaptic vesicle trafficking. In cultured mouse hippocampal neurons, synapsin III is expressed early during development, with levels peaking seven days after plating and declining thereafter. Synapsin III is highly concentrated in growth cones. Function: Synapsin III may be involved in the regulation of neurotransmitter release and synaptogenesis. It shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. Synapsin III contains a unique domain, J, located between domains C and E. Based on the Synapsin III gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is神经突触素3抗体 transcribed in the opposite direction. Subunit: Interacts with CAPON Subcellular Location: Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles. Tissue Specificity: Neuron specific. Detected predominantly in brain. Similarity: Belongs to the synapsin family. Gene ID: 8224 Database links: Entrez Gene: 8224 Human Entrez Gene: 29130 Rat Omim: 602705 Human SwissProt: O14994 Human SwissProt: O70441 Rat Unigene: 608750 Human Unigene: 162920 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经突触素3抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid