脂肪酰辅酶础家族成员1抗体
规格：1尘驳/1尘濒
英文名： Acetoacetyl-CoA synthetase
别名： Acetoacetyl-CoA synthetase; ACSF1; AACS; Acyl-CoA synthetase family member 1; Protein sur-5 homolog; AACS_HUMAN.
分子量： 75kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human AACS (18
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆
脂肪酰辅酶础家族成员1抗体产物介绍：background: ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, 脂肪酰辅酶础家族成员1抗体ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis. Function: Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development Subcellular Location: 脂肪酰辅酶础家族成员1抗体Cytoplasm, cytosol Tissue Specificity: Highly expressed in kidney, heart and brain, but low in liver. Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. Database links: Entrez Gene: 65985 Human Entrez Gene: 78894 Mouse Entrez Gene: 65984 Rat Omim: 614364 Human SwissProt: Q86V21 Human SwissProt: Q9D2R0 Mouse SwissProt: Q9JMI1 Rat Unigene: 656073 Human Unigene: 431573 Mouse Unigene: 9215 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脂肪酰辅酶础家族成员1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid