上皮钙粘附分子结合蛋白贰7
规格：1尘驳/1尘濒
英文名： Ecadherin binding protein E7
别名： c-Cbl-like protein 1; CasBrM (murine) ecotropic retroviral transforming sequencelike 1; Casitas B-lineage lymphoma transforming sequence-like protein 1; Casitas B-lineage lymphoma-like 1; Casitas B-li
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CBLL1/Ec
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：
上皮钙粘附分子结合蛋白贰7产物介绍：background: CBLL1, also known as HAKAI (meaning ‘destruction’ in Japanese), or RNF188 (RING finger protein 188), is a 491 amino acid protein that contains one C2H2-type zinc finger and one RING-type zinc finger. CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. More specifically, upon activation of c-Src, CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, thereby targeting the E-cadherin complex for endocytosis and disrupting epithelial cell-cell contacts. Via its role as上皮钙粘附分子结合蛋白贰7 an E-cadherin regulator, CBLL1 participates in cell adhesion and may also be involved in the regulation of epithelial-mesenchymal transitions. Function: Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation (By similarity). Subunit: Homodimer. Interacts with tyrosine-phosphorylated SRC substrates. Similarity:上皮钙粘附分子结合蛋白贰7 Contains 1 C2H2-type zinc finger. Contains 1 RING-type zinc finger. Database links: UniProtKB/Swiss-Prot: Q75N03.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
上皮钙粘附分子结合蛋白贰7产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid