动力结合蛋白顿狈惭叠笔抗体
规格：1尘驳/1尘濒
英文名： DNMBP
别名： Dnmbp; DNMBP_HUMAN; Dynamin binding protein; Dynamin-binding protein; KIAA1010; Scaffold protein TUBA; TUBA.
分子量： 177kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DNMBP
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：
动力结合蛋白顿狈惭叠笔抗体产物介绍：background: DNMBP, also known as Scaffold protein TUBA, is a 1,577 amino acid protein that localizes to a variety of locations within the cell, including the cytoplasm, cytoskeleton, cell junction and Golgi apparatus, and contains one BAR domain, one DH domain and six SH3 domains. Expressed in kidney, heart, lung, liver, brain, pancreas and skeletal muscle, Tuba functions as a scaffold protein that links Dynamin with Actin-regulating proteins and is thought to play a role in protein trafficking between the golgi and the cell surface. Two isoforms of Tuba exist due to alternative splicing events. The gene encoding Tuba maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple动力结合蛋白顿狈惭叠笔抗体 endocrine neoplasia type 2 and porphyria. Function: Scaffold protein that links dynamin with actin-regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). Subunit: Binds DNM1 via its N-terminal SH3 domains. The C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 and actin-regulatory proteins, such as ENAH, EVL, WASL, WIRE, CR16, WAVE1 and NAP1L1 (By similarity). Interacts with FASLG. Subcellular Location: Cytoplasm (By similarity). Golgi apparatus, Golgi stack (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell junction, synapse (By similarity). Note=Localized to synapses and Golgi stacks (By similarity). Tissue Specificity:动力结合蛋白顿狈惭叠笔抗体 Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Similarity: Contains 1 BAR domain. Contains 1 DH (DBL-homology) domain. Contains 6 SH3 domains. Database links: UniProtKB/Swiss-Prot: Q6XZF7.1 Entrez Gene: 23268 Human Entrez Gene: 71972 Mouse Entrez Gene: 309362 Rat Omim: 611282 Human SwissProt: Q6XZF7 Human SwissProt: Q6TXD4 Mouse Unigene: 500771 Human Unigene: 159024 Mouse Unigene: 11811 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
动力结合蛋白顿狈惭叠笔抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid