尿苷磷酸合成酶抗体
规格：1尘驳/1尘濒
英文名： UMPS
别名： ODC; Uridine 5-monophosphate synthase; OMPdecase; OPRT; OPRTase; Orotate phosphoribosyl transferase and orotidine 5' decarboxylase; Orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase
分子量： 52kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human UMPS
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, Cynomolgus Monkey, Rhesus monkey
细胞定位：细胞浆
尿苷磷酸合成酶抗体产物介绍：background: This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] Subunit: Homodimer. DISEASE: Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of 尿苷磷酸合成酶抗体cases have additional features, particularly congenital malformations and immune deficiencies. Similarity: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. In the C-terminal section; belongs to the OMP decarboxylase family. Gene ID: 7372 Database links: Entrez Gene: 460644 Chimpanzee Entrez Gene: 101124432 Gorilla Entrez Gene: 100070386 Horse Entrez Gene: 7372尿苷磷酸合成酶抗体 Human Entrez Gene: 22247 Mouse Entrez Gene: 100173867 Orangutan Entrez Gene: 715664 Rhesus monkey Omim: 613891 Human SwissProt: P11172 Human SwissProt: P13439 Mouse SwissProt: Q5R514 Orangutan Unigene: 2057 Human Unigene: 13145 Mouse Unigene: 466951 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
尿苷磷酸合成酶抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid