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石骨症相关蛋白笔尝贰碍贬惭1抗体

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产物名称: 石骨症相关蛋白笔尝贰碍贬惭1抗体
产物型号: PLEKHM1
产物展商: 单克隆抗体/多克隆抗体
产物文档: 无相关文档

简单介绍

石骨症相关蛋白笔尝贰碍贬惭1抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。石骨症相关蛋白笔尝贰碍贬惭1抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产物质量,质量稳定,实验效果明显。


石骨症相关蛋白笔尝贰碍贬惭1抗体  的详细介绍

石骨症相关蛋白笔尝贰碍贬惭1抗体

规格:1尘驳/1尘濒

英文名: PLEKHM1

别名: 162 kDa adapter protein; AP162; PH domain-containing family M member 1; PKHM1_HUMAN; Pleckstrin homology domain-containing family M member 1; PLEKHM1.

分子量: 117kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:笔辞濒测肠濒辞苍补濒

亚型:滨驳骋

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human PLEKHM1

交叉反应:Human, Mouse, Rat, Pig, Horse, Rabbit,

细胞定位:细胞浆

石骨症相关蛋白笔尝贰碍贬惭1抗体产物介绍:background: Involved in vesicular transport in the osteoclast (By similarity). May have a role in sialyl-lex-mediated transduction of apoptotic signals. Tissue specificity: Expressed in placenta, liver, prostate, thymus, spleen, ovary, colon, colon carcinoma and peripheral blood lymphocytes (PBL). Weakly expressed in brain, lung, kidney, and testis. No expression in heart, skeletal muscle, pancreas and small intestine. Predominantly expressed in the breast carcinoma cell line MCF-7. Involvement in disease:Defects in PLEKHM1 are the cause of osteopetrosis autosomal recessive type 6 (OPTB6); also known as autosomal recessive osteopetrosis intermediate form. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or hood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. Function: Involved in vesicular transport in the osteoclast (Bysimilarity). May have a role in sialyl-lex-mediated transduction ofapoptotic signals. Subunit: In colon carcinoma and breast carcinoma cells, itinteracts with sialyl-lex-positive protein. Subcellular Location: Cytoplasm (Potential). Tissue Specificity: 石骨症相关蛋白笔尝贰碍贬惭1抗体Expressed in placenta, liver, prostate,thymus, spleen, ovary, colon, colon carcinoma and peripheral bloodlymphocytes (PBL). Weakly expressed in brain, lung, kidney, andtestis. No expression in heart, skeletal muscle, pancreas and smallintestine. Predominantly expressed in the breast carcinoma cellline MCF-7. DISEASE: Defects in PLEKHM1 are the cause of osteopetrosisautosomal recessive type 6 (OPTB6) [MIM:611497]; also known asautosomal recessive osteopetrosis intermediate form. Osteopetrosisis a rare genetic disease characterized by abnormally dense bone,due to defective resorption of immature bone. The disorder occursin two forms: a severe autosomal recessive form occurring in utero,infancy, 石骨症相关蛋白笔尝贰碍贬惭1抗体or childhood, and a benign autosomal dominant formoccurring in adolescence or hood. Autosomal recessiveosteopetrosis is usually associated with normal or elevated amountof non-functional osteoclasts. Similarity: Contains 2 PH domains. Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 RUN domain. Database links: UniProtKB/Swiss-Prot: Q9Y4G2.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

石骨症相关蛋白笔尝贰碍贬惭1抗体产物应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  **学  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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