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铜代谢结构域蛋白1抗体

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产物名称: 铜代谢结构域蛋白1抗体
产物型号: COMMD1
产物展商: 单克隆抗体/多克隆抗体
产物文档: 无相关文档

简单介绍

铜代谢结构域蛋白1抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。铜代谢结构域蛋白1抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产物质量,质量稳定,实验效果明显。


铜代谢结构域蛋白1抗体  的详细介绍

铜代谢结构域蛋白1抗体

规格:1尘驳/1尘濒

英文名: COMMD1

别名: C2orf5; COMD1; COMD1_HUMAN; COMM domain-containing protein 1; COMMD1; copper metabolism domain containing 1; MGC27155; MURR1; Protein Murr1.

分子量: 21kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:笔辞濒测肠濒辞苍补濒

亚型:滨驳骋

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human COMMD1/M

交叉反应:Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,

细胞定位:

铜代谢结构域蛋白1抗体产物介绍:background: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Tissue specificity: Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta. Function: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Subunit: Monomer and homodimer. Interacts (via COMM domain) with COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8 and COMMD10 (via COMM domain). Identified in a 铜代谢结构域蛋白1抗体complex with an E3 ubiquitin ligase complex composed of TCEB1/elongin C, CUL2, SOCS1 and RBX1. Interacts directly with SOCS1 and CUL2. Interacts directly the N-terminal region of ATP7B. Interacts with CCS, CDKN2A, RELA and NFKBIB. Identified in a complex with NF-kappa-B. Interacts with CLU. Tissue Specificity: Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta. Post-translational modifications: Ubiquitinated; undergoes both 'Lys-63'- and 铜代谢结构域蛋白1抗体'Lys-48'-linked polyubiquitination. Ubiquitinated by XIAP, leading to its proteasomal degradation. Similarity: Contains 1 COMM domain. Database links: UniProtKB/Swiss-Prot: Q8N668.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. COMMD蛋白家族中*典型的成员.它是一个多效性因子,参与许多生理活动,包括铜代谢、钠运输、对核因子κB(NF-κB)及低氧诱导因子1(HIF-1)的调节等,COMMD广泛存在于多细胞生物中,*典型的特征是它们的羧基端存在一个高度保守而独特的结构—COMMD结构域,为蛋白质间的相互作用提供了关键界面. 目前研究COMMD蛋白家族有10个成铜代谢结构域蛋白1抗体员,即颁翱惭惭顿1~10.颁翱惭惭顿1是颁翱惭惭顿蛋白家族中*先被证实且研究*为深入的蛋白质,在不同物种中广泛表达,在人类的不同组织表达存在差异.

产物应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  信号转导  表观遗传学  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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