骨骼肌细胞线粒体膜蛋白笔础搁尝抗体
规格：1尘驳/1尘濒
英文名： PARL
别名： Mitochondrial intramembrane cleaving protease PARL; Mitochondrial intramembrane-cleaving protease PARL; P-beta; parl; PARL_HUMAN; Pbeta; presenilin associated rhomboid-like; Presenilins associated rho
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PARL
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
细胞定位：细胞核 细胞浆 细胞膜
骨骼肌细胞线粒体膜蛋白笔础搁尝抗体产物介绍：background: Presenilins associated rhombiod-like protein (PARL) is a mitochondrial intramembrane-cleaving protease belonging to the S54 family of proteins. PARL is involved in intramembrane regulated proteolysis as its catalytic activity involves the cleaving of signaling proteins at intracellular membranes to release active fragments in signal transduction cascades. Using a triad of histidine, serine and asparagine, PARL cleaves type-1 transmembrane domains. PARL is a multi-pass membrane protein localizing to the inner and outer mitochondrial membranes, but it can also be detected in the nucleus following proteolytical processing of P-β. PARL co-localizes with the presenilins PSEN1 and PSEN2, the familial Alzheimer disease products. Function: Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in 骨骼肌细胞线粒体膜蛋白笔础搁尝抗体response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. Subcellular Location: Mitochondrion inner membrane and Nucleus. Translocated into the nucleus by an unknown mechanism. Post-translational modifications: P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner.骨骼肌细胞线粒体膜蛋白笔础搁尝抗体 The cleavage is inhibited when residues Ser-65, Thr-69 and Ser-70 are all phosphorylated. Similarity: Belongs to the peptidase S54 family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
骨骼肌细胞线粒体膜蛋白笔础搁尝抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞凋亡 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid