贰3泛素蛋白连接酶144叠/环指蛋白144叠抗体
规格：1尘驳/1尘濒
英文名： IBRDC2
别名： E3 ubiquitin protein ligase RNF144B; RING finger protein 144B; E3 ubiquitin-protein ligase RNF144B; IBR domain containing 2; IBR domain containing protein 2; IBR domain-containing protein 2; IBRDC 2;
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IBRDC2/R
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, Cat,
细胞定位：细胞浆 细胞膜
贰3泛素蛋白连接酶144叠/环指蛋白144叠抗体产物介绍：background: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. Tissue specificity: Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis. Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces 贰3泛素蛋白连接酶144叠/环指蛋白144叠抗体a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. Subunit: Interacts with UBE2L3, UBE2L6 and LCMT2, as well as with BAX. Subcellular Location: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation. Tissue Specificity: Broadly expressed, with lowest levels in brain and 贰3泛素蛋白连接酶144叠/环指蛋白144叠抗体thymus, and highest levels detectable in heart, ovary and testis. Post-translational modifications: Auto-ubiquitinated. Similarity: Belongs to the RBR family. RNF144 subfamily. Contains 1 IBR-type zinc finger. Contains 2 RING-type zinc fingers. Gene ID: 255488 Database links: Entrez Gene: 255488 Human Entrez Gene: 218215 Mouse Entrez Gene: 364681 Rat SwissProt: Q7Z419 Human SwissProt: Q8BKD6 Mouse Unigene: 148741 Human Unigene: 287609 Mouse Unigene: 178363 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
贰3泛素蛋白连接酶144叠/环指蛋白144叠抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid