钙调神经磷酸酶调节蛋白2/唐氏综合征候选区域蛋白1样蛋白2抗体
规格：1尘驳/1尘濒
英文名： Calcipressin 2
别名： DSCR1L1; Calcipressin 2; Calcipressin-2; CSP2; Down syndrome candidate region 1-like 1; Down syndrome critical region gene 1 like 1 protein; MCIP2; Myocyte enriched calcineurin interacting protein 2;
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Calcipre
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
细胞定位：
钙调神经磷酸酶调节蛋白2/唐氏综合征候选区域蛋白1样蛋白2抗体产物介绍：background: Calcineurin is a Ca(2+) dependent protein phosphatase that is involed in several neuornal functions. Proteins belonging to the RCAN (Regulator of calcineurin) family modulate the activity of Calcineurin through a valine-rich region within their carboxyl tail. RCANs compete with NFATs (Nuclear factor of activated T-cells) for binding to the same docking site in calcineurin, which results in either inhibition or activation of calcineurin activity. Calcipressin-2, also known as RCAN2 and DSCR1L1 (Down syndrome candidate region 1-like 1), is a 197 amino acid protein that is highly expressed in both the cytoplasm and nucleus of neurons and is the only RCAN family member that is found in glial cells. Calcipressin-3, also known as RCAN3 and DSCR1L2 (Down syndrome candidate region 1-like protein 2), is a 241 amino acid protein that potentially is involved in central nervous system development. Calcipressin-3钙调神经磷酸酶调节蛋白2/唐氏综合征候选区域蛋白1样蛋白2抗体 interacts with cardiac troponin I, suggesting that it may play a role in cardiac contraction events. Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Tissue Specificity: Expressed in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas. Similarity: Belongs to the RCAN family. Gene ID: 10231 Database links: Entrez Gene: 10231 Human Entrez钙调神经磷酸酶调节蛋白2/唐氏综合征候选区域蛋白1样蛋白2抗体 Gene: 53901 Mouse Entrez Gene: 140666 Rat Omim: 604876 Human SwissProt: Q14206 Human SwissProt: Q9JHG2 Mouse SwissProt: Q8CH27 Rat Unigene: 440168 Human Unigene: 710016 Human Unigene: 251242 Mouse Unigene: 24428 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钙调神经磷酸酶调节蛋白2/唐氏综合征候选区域蛋白1样蛋白2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 染色质和核信号 神经生物学 信号转导 细胞凋亡 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid