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巢蛋白1抗体

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产物名称: 巢蛋白1抗体
产物型号: Nidogen
产物展商: 单克隆抗体/多克隆抗体
产物文档: 无相关文档

简单介绍

巢蛋白1抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。巢蛋白1抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产物质量,质量稳定,实验效果明显。


巢蛋白1抗体  的详细介绍

巢蛋白1抗体

规格:1尘驳/1尘濒

英文名: Nidogen

别名: Ent; Entactin 1; Entactin; NID 1; NID; NID-1; Nid1; NID1_HUMAN; Nidogen (enactin); Nidogen 1; Nidogen; Nidogen-1; NID1_HUMAN.

分子量: 133kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:笔辞濒测肠濒辞苍补濒

亚型:滨驳骋

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human Entactin

交叉反应:Human, Mouse, Rat, Cow, Rabbit,

细胞定位:细胞膜 细胞外基质 分泌型蛋白

巢蛋白1抗体产物介绍:background: Basement membranes are the earliest extracellular matrices produced during embryogenesis. They are synthesized and incorporated into the supramolecular architecture of several components, including laminins, Collagen IV, Nidogen and proteoglycans. Nidogen/Entactin, a sulfated glycoprotein, acts as a link between the extracellular matrix molecules Laminin 1 and Collagen Type IV, and thereby participates in the assembly of basement membranes. Nidogen is a highly conserved member of the Nidogen family, which also includes Nidogen-2. Nidogen-2 has a high level of N- and O-glycosylation, and it interacts with Collagens Type I and IV and Perlecan at a comparable level to Nidogen. Nidogen is synthesized and secreted in primary and established mesenchymal peritubular cells and myoepithelial cells, and it affects adhesion of peritubular cells in an autocrine manner. Nidogen is expressed during embryonic and fetal development exclusively in fully developed basement membranes of the ectoderm and is not expressed in the developing endodermal basement membrane or in巢蛋白1抗体 membranes disrupted during mesoderm formation. Nidogen also cooperates with Laminin 1 to regulate b-casein expression. Function: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. Subunit: Interacts with FBLN1 and LGALS3BP. Interacts with PLXDC1. Subcellular Location: 巢蛋白1抗体Secreted, extracellular space, extracellular matrix, basement membrane. Post-translational modifications: N- and O-glycosylated. Similarity: Contains 6 EGF-like domains. Contains 1 NIDO domain. Contains 1 nidogen G2 beta-barrel domain. Contains 1 thyroglobulin type-1 domain. Database links: UniProtKB/Swiss-Prot: P14543.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

巢蛋白1抗体产物应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  **学  神经生物学  信号转导  细胞周期蛋白  细胞粘附分子  细胞分化  细胞骨架  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid




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