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SHMT2抗体经ICC, IHC严格验证,品质保证.适用于多种种属反应性,被多篇文献引用并有用户反馈信息.确保特异性!产物具有以下特点:

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产物编号xy-17469R

英文名称厂贬惭罢2

中文名称丝氨酸甲基化酶尘厂贬惭罢抗体

别    名GLY A+; GLYA; glycine auxotroph A, human complement for hamster; Glycine hydroxymethyltransferase; GLYM_HUMAN; mitochondrial; Serine hydroxymethyltransferase 2 (mitochondrial); Serine hydroxymethyltransferase; Serine hydroxymethyltransferase mitochondrial; Serine methylase; SHMT 2; SHMT; SHMT2.  

说 明 书100ul  200ul

研究领域肿瘤  细胞生物  信号转导  新陈代谢  

抗体来源搁补产产颈迟

克隆类型笔辞濒测肠濒辞苍补濒

SHMT2抗体交叉反应 Human, Mouse, Rat,

产物应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量56kDa

细胞定位细胞浆

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human SHMT2

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产物介绍产补肠办驳谤辞耻苍诲:

This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Function:

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA.

Subcellular Location:

Mitochondrion. Mitochondrion matrix > mitochondrion nucleoid. Mitochondrion inner membrane.

Similarity:

Belongs to the SHMT family.

SWISS:

P34897

Gene ID:

6472